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Anti-ARC (E194) Antibody

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产品名称: Anti-ARC (E194) Antibody
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Anti-ARC (E194) Antibody


Anti-ARC (E194) Antibody  的详细介绍
Name: Anti-ARC (E194) Antibody
See all ARC primary antibodies
Description: Rabbit polyclonal antibody to ARC (E194)
Specificity: ARC (E194) pAb detects endogenous levels of ARC protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 161-210 of Human ARC.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 24 or 28 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Isoform 1: May be involved in RNA splicing.
Tissue Specificity: Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver, kidney and pancreas.
Involvement in Disease: Myoclonus, familial cortical: An autosomal dominant neurologic condition characterized by ***** onset of cortical myoclonus manifest as involuntary jerks or movements affecting the face and limbs. Affected individuals can also experience falls without seizure activity or loss of consciousness.
Post-Translational Modification: Phosphorylation at Thr-149 is required for its antiapoptotic effect by blocking death-inducing signaling complex death-inducing signaling complex (DISC) activity through the control of interaction with CASP8. Phosphorylation at Thr-149 results in translocation to mithochondria and this translocation enables the binding to CASP8. Dephosphorylated at Thr-149 by calcineurin; doesn't inhibit the association between FADD and CASP8 and the consequent apoptosis.
Cellular Location: Nucleus > Nucleolus.

The SR-rich C-terminus mediates nuclear localization.
Database Links:
  • Entrez Gene: 23237?Human
  • Entrez Gene: 11838?Mouse
  • Entrez Gene: 54323?Rat
  • Omim: 612461?Human
  • SwissProt: Q7LC44?Human
  • SwissProt: Q9WV31?Mouse
  • SwissProt: Q63053?Rat
  • Unigene: 40888?Human
  • Unigene: 741621?Human
  • Unigene: 25405?Mouse
  • Unigene: 10086?Rat
    		•
    Synonyms:
  • activity regulated cytoskeleton associated protein Antibody
  • activity regulated gene 3.1 protein homolog Antibody
  • Activity-regulated cytoskeleton-associated protein Antibody
  • Activity-regulated gene 3.1 protein homolog Antibody
  • Arc Antibody
  • ARC/ARG3.1 Antibody
  • ARC_HUMAN Antibody
  • Arg3.1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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