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Anti-AR Antibody

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产品名称: Anti-AR Antibody
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简单介绍

Anti-AR Antibody


Anti-AR Antibody  的详细介绍
Name: Anti-AR Antibody
See all Androgen Receptor primary antibodies
Description: Goat polyclonal antibody to AR.
Applications: ELISA, WB, IHC, ChIP
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human AR (N terminal).
Sequence: EVQLGLGRVYPRPPSC
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Tissue Specificity: Isoform 2 is mainly expressed in heart and skeletal muscle (PubMed:15634333). Isoform 3 is expressed by basal and stromal cells of prostate (at protein level) (PubMed:19244107).
Involvement in Disease: Androgen insensitivity syndrome: An X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype.

Spinal and bulbar muscular atrophy X-linked 1: An X-linked recessive form of spinal muscular atrophy. Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX1 occurs only in men. Age at onset is usually in the third to fifth decade of life, but earlier involvement has been reported. It is characterized by slowly progressive limb and bulbar muscle weakness with fasciculations, muscle atrophy, and gynecomastia. The disorder is clinically similar to classic forms of autosomal spinal muscular atrophy.

Androgen insensitivity, partial: A disorder that is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR3 subfamily.
Post-Translational Modification: Sumoylated on Lys-388 (major) and Lys-521. Ubiquitinated. Deubiquitinated by USP26. 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity.
Cellular Location: Nucleus. Cytoplasm.

Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.
Database Links:
  • Entrez Gene: 367?Human
  • Omim: 313700?Human
  • SwissProt: P10275?Human
  • Unigene: 76704?Human
    		•
    Synonyms:
  • AIS Antibody
  • Androgen nuclear receptor variant 2 Antibody
  • Androgen Receptor Antibody
  • Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) Antibody
  • androgen receptor splice variant 4b Antibody
  • ANDR_HUMAN Antibody
  • AR Antibody
  • AR8 Antibody
  • DHTR Antibody
  • Dihydro testosterone receptor Antibody
  • Dihydrotestosterone receptor Antibody
  • Dihydrotestosterone receptor (DHTR) Antibody
  • HUMARA Antibody
  • HYSP1 Antibody
  • KD Antibody
  • Kennedy disease (KD) Antibody
  • NR3C4 Antibody
  • Nuclear receptor subfamily 3 group C member 4 Antibody
  • Nuclear receptor subfamily 3 group C member 4 (NR3C4) Antibody
  • SBMA Antibody
  • SMAX1 Antibody
  • Spinal and bulbar muscular atrophy Antibody
  • Spinal and bulbar muscular atrophy (SBMA) Antibody
  • Testicular Feminization (TFM) Antibody
  • TFM Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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