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Anti-APOBEC3G Antibody

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产品名称: Anti-APOBEC3G Antibody
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Anti-APOBEC3G Antibody


Anti-APOBEC3G Antibody  的详细介绍
Name: Anti-APOBEC3G Antibody
See all APOBEC3G primary antibodies
Description: Rabbit polyclonal antibody to APOBEC3G
Specificity: The antibody detects endogenous level of total APOBEC3G protein.
Applications: WB, IHC, IF
Reactivity: Human
Immunogen: Recombinant protein of human APOBEC3G.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
Tissue Specificity: Expressed in spleen, testes, ovary and peripheral blood leukocytes and CD4+ lymphocytes. Also expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines; no expression detected in permissive lymphoid and non-lymphoid cell lines. Exists only in the LMM form in peripheral blood-derived resting CD4 T-cells and monocytes, both of which are refractory to HIV-1 infection. LMM is converted to a HMM complex when resting CD4 T-cells are activated or when monocytes are induced to differentiate into macrophages. This change correlates with increased susceptibility of these cells to HIV-1 infection.
Sequence Similarities: Belongs to the cytidine and deoxycytidylate deaminase family.
Post-Translational Modification: Ubiquitinated in the presence of HIV-1 VIF. Association with VIF targets the protein for proteolysis by the ubiquitin-dependent proteasome pathway.
Cellular Location: Cytoplasm. Nucleus. Cytoplasm > P-body.

Mainly cytoplasmic. Small amount are found in the nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 VIF.
Database Links:
  • Entrez Gene: 200316?Human
  • Entrez Gene: 60489?Human
  • Omim: 607113?Human
  • SwissProt: Q9HC16?Human
  • Unigene: 659809?Human
  • Unigene: 660143?Human
    		•
    Synonyms:
  • A3G Antibody
  • ABC3G_HUMAN Antibody
  • APOBEC related cytidine deaminase Antibody
  • APOBEC related protein Antibody
  • APOBEC-related cytidine deaminase Antibody
  • APOBEC-related protein Antibody
  • APOBEC-related protein 9 Antibody
  • APOBEC3G Antibody
  • Apolipoprotein B editing enzyme catalytic polypeptide like 3G Antibody
  • Apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G Antibody
  • Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G Antibody
  • Apolipoprotein B mRNA editing enzyme catalytic subunit 3G Antibody
  • apolipoprotein B mRNA editing enzyme cytidine deaminase Antibody
  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like Antibody
  • ARCD Antibody
  • ARP-9 Antibody
  • ARP9 Antibody
  • bK150C2.7 Antibody
  • CEM-15 Antibody
  • CEM15 Antibody
  • deoxycytidine deaminase Antibody
  • dJ494G10.1 Antibody
  • DNA dC dU editing enzyme APOBEC 3G Antibody
  • DNA dC->dU editing enzyme Antibody
  • DNA dC->dU-editing enzyme APOBEC-3G Antibody
  • EC 3.5.4. Antibody
  • FLJ12740 Antibody
  • MDS019 Antibody
  • OTTHUMP00000028911 Antibody
  • phorbolin-like protein Antibody
  • phorbolin-like protein MDS019 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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