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Anti-APBB1 Antibody

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产品名称: Anti-APBB1 Antibody
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简单介绍

Anti-APBB1 Antibody


Anti-APBB1 Antibody  的详细介绍
Name: Anti-APBB1 Antibody
See all APBB1 primary antibodies
Description: Rabbit polyclonal antibody to APBB1.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human APBB1.
Protein Length: 710(708)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
Tissue Specificity: Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
Post-Translational Modification: Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). Phosphorylated following nuclear translocation. Phosphorylation at Tyr-547 by ABL1 enhances transcriptional activation activity and reduces the affinity for RASD1/DEXRAS1.
Cellular Location: Cell membrane. Cytoplasm. Nucleus. Cell projection > Growth cone. Nucleus speckle.

Colocalizes with TSHZ3 in axonal growth cone (By similarity). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP. Colocalizes with TSHZ3 in the nucleus. Colocalizes with NEK6 at the nuclear speckles. Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity).
Database Links:
  • Entrez Gene: 322?Human
  • Entrez Gene: 11785?Mouse
  • Entrez Gene: 29722?Rat
  • Omim: 602709?Human
  • SwissProt: O00213?Human
  • SwissProt: Q9QXJ1?Mouse
  • SwissProt: P46933?Rat
  • Unigene: 372840?Human
  • Unigene: 38469?Mouse
  • Unigene: 19953?Rat
    		•
    Synonyms:
  • Adaptor protein FE65a2 Antibody
  • Amyloid beta (A4) precursor protein binding family B member 1 Antibody
  • Amyloid beta A4 precursor protein binding family B Antibody
  • Amyloid beta A4 precursor protein binding family B member 1 Antibody
  • Amyloid beta A4 precursor protein-binding family B member 1 Antibody
  • Amyloid beta precursor protein binding family B member 1 Antibody
  • APBB 1 Antibody
  • APBB1 Antibody
  • APBB1_HUMAN Antibody
  • FE 65 Antibody
  • FE65 Antibody
  • Fe65 protein Antibody
  • Protein Fe65 Antibody
  • RIR Antibody
  • stat like protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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