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Anti-AP2B1 Antibody

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产品名称: Anti-AP2B1 Antibody
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Anti-AP2B1 Antibody


Anti-AP2B1 Antibody  的详细介绍
Name: Anti-AP2B1 Antibody
See all AP2B1 primary antibodies
Description: Rabbit polyclonal antibody to AP2B1
Specificity: The antibody detects endogenous level of total AP2B1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human AP2B1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.
Sequence Similarities: Belongs to the adaptor complexes large subunit family.
Post-Translational Modification: Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles (CCVs).
Cellular Location: Cell membrane. Membrane > Coated pit.

AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
Database Links:
  • Entrez Gene: 163?Human
  • Entrez Gene: 71770?Mouse
  • Entrez Gene: 140670?Rat
  • Omim: 601025?Human
  • SwissProt: P63010?Human
  • SwissProt: Q9DBG3?Mouse
  • SwissProt: P62944?Rat
  • Unigene: 514819?Human
  • Unigene: 39053?Mouse
  • Unigene: 56138?Rat
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    Synonyms:
  • Adapter related protein complex 2 beta 1 subunit Antibody
  • Adapter-related protein complex 2 beta subunit Antibody
  • Adaptin, beta 2 (beta) Antibody
  • Adaptor protein complex AP-2 subunit beta Antibody
  • Adaptor related protein complex 2, beta 1 subunit Antibody
  • ADTB2 Antibody
  • AP-2 complex subunit beta Antibody
  • AP105B Antibody
  • AP2 BETA Antibody
  • AP2B1 Antibody
  • AP2B1_HUMAN Antibody
  • Beta adaptin Antibody
  • Beta-2-adaptin Antibody
  • Beta-adaptin Antibody
  • Beta2 adaptin Antibody
  • CLAPB1 Antibody
  • Clathrin assembly protein complex 2 beta large chain Antibody
  • Clathrin associated/assembly/adaptor protein, large, beta 1 Antibody
  • DKFZp781K0743 Antibody
  • Plasma membrane adaptor HA2/AP2 adaptin beta subunit Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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