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Anti-Annexin I (N146) Antibody

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产品名称: Anti-Annexin I (N146) Antibody
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Anti-Annexin I (N146) Antibody


Anti-Annexin I (N146) Antibody  的详细介绍
Name: Anti-Annexin I (N146) Antibody
See all Annexin I primary antibodies
Description: Rabbit polyclonal antibody to Annexin I (N146)
Specificity: Annexin I (N146) pAb detects endogenous levels of Annexin I protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 111-160 of Human Annexin I.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 39 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
Tissue Specificity: Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.
Sequence Similarities: Belongs to the annexin family.
Post-Translational Modification: Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504).
Cellular Location: Nucleus. Cytoplasm. Cell projection > Cilium. Cell membrane. Membrane. Endosome membrane. Basolateral cell membrane. Apical cell membrane. Lateral cell membrane. Secreted. Secreted > Extracellular space. Cell membrane. Secreted > Exosome. Cytoplasmic vesicle > Secretory vesicle lumen. Cell projection > Phagocytic cup. Early endosome. Cytoplasmic vesicle membrane.

Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678).
Database Links:
  • Entrez Gene: 301?Human
  • Entrez Gene: 16952?Mouse
  • Entrez Gene: 25380?Rat
  • Omim: 151690?Human
  • SwissProt: P04083?Human
  • SwissProt: P10107?Mouse
  • SwissProt: P07150?Rat
  • Unigene: 494173?Human
  • Unigene: 248360?Mouse
  • Unigene: 1792?Rat
    		•
    Synonyms:
  • Annexin A1 Antibody
  • Annexin I Antibody
  • Annexin-1 Antibody
  • AnnexinI Antibody
  • ANX 1 Antibody
  • ANX1 Antibody
  • ANXA 1 Antibody
  • ANXA1 Antibody
  • ANXA1_HUMAN Antibody
  • Calpactin II Antibody
  • Calpactin-2 Antibody
  • Chromobindin 9 Antibody
  • Chromobindin-9 Antibody
  • Lipocortin I Antibody
  • LPC 1 Antibody
  • LPC1 Antibody
  • p35 Antibody
  • Phospholipase A2 inhibitory protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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