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Anti-AMPKβ1 (phospho-S181) Antibody

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产品名称: Anti-AMPKβ1 (phospho-S181) Antibody
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简单介绍

Anti-AMPKβ1 (phospho-S181) Antibody


Anti-AMPKβ1 (phospho-S181) Antibody  的详细介绍
Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Sequence Similarities: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
Post-Translational Modification: Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
Database Links:
  • Entrez Gene: 5564 Human
  • Entrez Gene: 19079 Mouse
  • Entrez Gene: 83803 Rat
  • Omim: 602740 Human
  • SwissProt: Q9Y478 Human
  • SwissProt: Q9R078 Mouse
  • SwissProt: P80386 Rat
  • Unigene: 726001 Human
  • Unigene: 741184 Human
  • Unigene: 458152 Mouse
  • Unigene: 3619 Rat
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    Synonyms:
  • 1300015D22Rik Antibody
  • 5''-AMP-activated protein kinase subunit beta-1 Antibody
  • 5'-AMP-activated protein kinase beta-1 subunit Antibody
  • AAKB1_HUMAN Antibody
  • AMP-activated protein kinase beta subunit Antibody
  • AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1 Antibody
  • AMP-activated, noncatalytic, beta-1 Antibody
  • AMPK Antibody
  • AMPK beta 1 Antibody
  • AMPK beta 1 chain Antibody
  • AMPK subunit beta-1 Antibody
  • AMPK-BETA-1 Antibody
  • AMPKb Antibody
  • AU021155 Antibody
  • E430008F22 Antibody
  • HAMPKb Antibody
  • MGC17785 Antibody
  • PRKAB1 Antibody
  • Protein kinase AMP activated non catalytic subunit beta 1 Antibody
  • protein kinase, AMP-activated, beta 1 non-catalytic subunit Antibody
  • protein kinase, AMP-activated, noncatalytic, beta-1 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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