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Anti-ALOX5 (E267) Antibody

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产品名称: Anti-ALOX5 (E267) Antibody
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Anti-ALOX5 (E267) Antibody


Anti-ALOX5 (E267) Antibody  的详细介绍
Name: Anti-ALOX5 (E267) Antibody
See all ALOX5 primary antibodies
Description: Rabbit polyclonal antibody to ALOX5 (E267)
Specificity: ALOX5 (E267) pAb detects endogenous levels of ALOX5 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 231-280 of Human ALOX5.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 78 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Sequence Similarities: Belongs to the lipoxygenase family.
Post-Translational Modification: Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
Cellular Location: Cytoplasm. Nucleus matrix. Nucleus membrane.

Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
Database Links:
  • Entrez Gene: 240?Human
  • Entrez Gene: 11689?Mouse
  • Entrez Gene: 25290?Rat
  • Omim: 152390?Human
  • SwissProt: P09917?Human
  • SwissProt: P48999?Mouse
  • SwissProt: P12527?Rat
  • Unigene: 89499?Human
  • Unigene: 41072?Mouse
  • Unigene: 9662?Rat
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    Synonyms:
  • 5 Lipoxygenase Antibody
  • 5 LO Antibody
  • 5 LOX Antibody
  • 5-lipoxygenase Antibody
  • 5-LO Antibody
  • 5-LOX Antibody
  • 5LOX Antibody
  • 5LPG Antibody
  • ALOX 5 Antibody
  • Alox5 Antibody
  • Arachidonate 5 lipoxygenase Antibody
  • Arachidonate 5-lipoxygenase Antibody
  • arachidonic 5-lipoxygenase alpha-10 isoform Antibody
  • arachidonic 5-lipoxygenase delta-10-13 isoform Antibody
  • arachidonic 5-lipoxygenase delta-13 isoform Antibody
  • arachidonic 5-lipoxygenase delta-p10 isoform Antibody
  • Arachidonic acid 5 lipoxygenase Antibody
  • Leukotriene A4 synthase Antibody
  • LOG 5 Antibody
  • LOG5 Antibody
  • LOX5_HUMAN Antibody
  • MGC163204 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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