产品资料

Anti-AIM2 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-AIM2 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-AIM2 Antibody


Anti-AIM2 Antibody  的详细介绍
Name: Anti-AIM2 Antibody
See all AIM2 primary antibodies
Description: Goat polyclonal antibody to AIM2.
Applications: ELISA, WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human AIM2 (C terminal).
Sequence: C-GEKLQLTSGVHSTIK
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Tissue Specificity: Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.
Sequence Similarities: Belongs to the HIN-200 family.
Cellular Location: Nucleus. Cytoplasm.

Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Database Links:
  • Entrez Gene: 9447?Human
  • Omim: 604578?Human
  • SwissProt: O14862?Human
  • Unigene: 281898?Human
  • Unigene: 733411?Human
    		•
    Synonyms:
  • Absent in melanoma 2 Antibody
  • AIM 2 Antibody
  • AIM2 Antibody
  • AIM2_HUMAN Antibody
  • Interferon-inducible protein AIM2 Antibody
  • OTTHUMP00000035296 Antibody
  • PYHIN4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号