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Anti-AIM2 Antibody

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产品名称: Anti-AIM2 Antibody
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简单介绍

Anti-AIM2 Antibody


Anti-AIM2 Antibody  的详细介绍
Name: Anti-AIM2 Antibody
See all AIM2 primary antibodies
Description: Rabbit polyclonal antibody to AIM2
Applications: ELISA, IHC, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Mouse
Immunogen: Synthetic peptide taken within amino acid region 240-340 on human AIM2 protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Concentration: 0.58 μg/μl in antibody stabilization buffer
Storage: -20?C for long term storage
Function: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Tissue Specificity: Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.
Sequence Similarities: Belongs to the HIN-200 family.
Cellular Location: Nucleus. Cytoplasm.

Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Database Links:
  • Entrez Gene: 9447?Human
  • Entrez Gene: 383619?Mouse
  • Omim: 604578?Human
  • SwissProt: O14862?Human
  • SwissProt: Q91VJ1?Mouse
  • Unigene: 281898?Human
  • Unigene: 733411?Human
  • Unigene: 131453?Mouse
    		•
    Synonyms:
  • Absent in melanoma 2 Antibody
  • AIM 2 Antibody
  • AIM2 Antibody
  • AIM2_HUMAN Antibody
  • Interferon-inducible protein AIM2 Antibody
  • OTTHUMP00000035296 Antibody
  • PYHIN4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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