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Antibodies
Anti-ADIPOQ Antibody
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产品名称:
Anti-ADIPOQ Antibody
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简单介绍
Anti-ADIPOQ
Antibody
Anti-ADIPOQ Antibody
的详细介绍
Overview
Name:
Anti-ADIPOQ
Antibody
See all ADIPOQ primary antibodies
Description:
Rabbit polyclonal antibody to ADIPOQ.
Applications:
WB, IHC
Dilutions:
WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:
Human, Mouse, Rat
Immunogen:
Recombinant protein of human ADIPOQ.
Protein Length:
244
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purification:
Affinity purification.
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Tissue Specificity:
Synthesized exclusively by adipocytes and secreted into plasma.
Involvement in Disease:
Adiponectin deficiency: A condition that results in very low concentrations of plasma adiponectin.
Diabetes mellitus, non-insulin-dependent: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Post-Translational Modification:
Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal peptide in mass fingerprinting.
Cellular Location:
Secreted.
Database Links:
Entrez Gene: 9370?Human
Entrez Gene: 11450?Mouse
Entrez Gene: 246253?Rat
Omim: 605441?Human
SwissProt: Q15848?Human
SwissProt: Q60994?Mouse
Unigene: 80485?Human
Unigene: 3969?Mouse
Synonyms:
30 kDa adipocyte complement related protein Antibody
30 kDa adipocyte complement-related protein Antibody
ACDC Antibody
ACRP30 Antibody
Adipocyte Antibody
Adipocyte C1q and collagen domain containing protein Antibody
Adipocyte complement related 30 kDa protein Antibody
Adipocyte complement related protein of 30 kDa Antibody
Adipocyte complement-related 30 kDa protein Antibody
adipocyte-specific secretory protein Antibody
Adiponectin Antibody
Adiponectin precursor Antibody
adiponectin, C1Q and collagen domain containing Antibody
Adipoq Antibody
Adipose most abundant gene transcript 1 Antibody
Adipose most abundant gene transcript 1 protein Antibody
Adipose specific collagen like factor Antibody
ADIPO_HUMAN Antibody
ADIPQTL1 Antibody
ADPN Antibody
APM 1 Antibody
apM-1 Antibody
APM1 Antibody
C1q and collagen domain-containing protein Antibody
GBP28 Antibody
Gelatin binding protein Antibody
Gelatin binding protein 28 Antibody
Gelatin-binding protein Antibody
Information:
Target information shown above is from the UniProt Consortium.
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