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Anti-Active Caspase-3 Antibody

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产品名称: Anti-Active Caspase-3 Antibody
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简单介绍

Anti-Active Caspase-3 Antibody


Anti-Active Caspase-3 Antibody  的详细介绍
Name: Anti-Active Caspase-3 Antibody
See all Active Caspase-3 primary antibodies
Description: Rabbit monoclonal antibody to Active Caspase-3.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity: Human
Immunogen: Recombinant protein of human CASP3.
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Tissue Specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 836?Human
  • Omim: 600636?Human
  • SwissProt: P42574?Human
  • Unigene: 141125?Human
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    Synonyms:
  • active Caspase-3 Antibody
  • Apopain Antibody
  • CASP 3 Antibody
  • CASP-3 Antibody
  • CASP3 Antibody
  • CASP3_HUMAN Antibody
  • Caspase 3 Antibody
  • Caspase-3 subunit p12 Antibody
  • cleaved caspase 3 Antibody
  • CPP 32 Antibody
  • CPP-32 Antibody
  • CPP32B Antibody
  • Cysteine protease CPP32 Antibody
  • PARP cleavage protease Antibody
  • Protein Yama Antibody
  • SCA-1 Antibody
  • SCA1 Antibody
  • SREBP cleavage activity 1 Antibody
  • Yama Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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