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Anti-Actin-α3/γ2 (E2) Antibody

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产品名称: Anti-Actin-α3/γ2 (E2) Antibody
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Anti-Actin-α3/γ2 (E2) Antibody


Anti-Actin-α3/γ2 (E2) Antibody  的详细介绍
Name: Anti-Actin-α3/γ2 (E2) Antibody
See all Actin-α3 primary antibodies
Description: Rabbit polyclonal antibody to Actin-α3/γ2 (E2)
Specificity: Actin-α3/γ2 (E2) pAb detects endogenous levels of Actin-α3/γ2 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to the N-terminal of Human Actin-α3/γ2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 45 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Involvement in Disease: Visceral myopathy: A rare inherited form of myopathic pseudo-obstruction characterized by impaired function of enteric smooth muscle cells, resulting in abnormal intestinal motility, severe abdominal pain, malnutrition, and even death. The disease shows inter- and intrafamilial variability. Most severely affected patients exhibit prenatal bladder enlargement, intestinal malrotation, neonatal functional gastrointestinal obstruction, and dependence on total parenteral nutrition and urinary catheterization.
Sequence Similarities: Belongs to the actin family.
Post-Translational Modification: Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
Cellular Location: Cytoplasm > Cytoskeleton.
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