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Anti-Vimentin Antibody

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产品名称: Anti-Vimentin Antibody
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Anti-Vimentin Antibody


Anti-Vimentin Antibody  的详细介绍
Name: Anti-Vimentin Antibody
See all Vimentin primary antibodies
Description: Mouse monoclonal antibody to Vimentin
Specificity: This antibody detects endogenous levels of Vimentin and does not cross-react with related proteins.
Applications: WB, ICC, IHC, FC
Reactivity: Human, Mouse, Rat
Immunogen: This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to a region of Vimentin.
Host: Mouse
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: ~ 54 kDa
Purity: Protein A affinity purified
Product Form: Mouse IgG1. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Function: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Tissue Specificity: Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
Involvement in Disease: Cataract 30: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
Sequence Similarities: Belongs to the intermediate filament family.
Post-Translational Modification: Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 7431?Human
  • Entrez Gene: 22352?Mouse
  • Entrez Gene: 81818?Rat
  • Omim: 193060?Human
  • SwissProt: P08670?Human
  • SwissProt: P20152?Mouse
  • SwissProt: P31000?Rat
  • Unigene: 455493?Human
  • Unigene: 691131?Human
  • Unigene: 268000?Mouse
  • Unigene: 2710?Rat
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    Synonyms:
  • CTRCT30 Antibody
  • Epididymis luminal protein 113 Antibody
  • FLJ36605 Antibody
  • HEL113 Antibody
  • VIM Antibody
  • Vimentin Antibody
  • VIME_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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