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Anti-UHRF1 Antibody

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产品名称: Anti-UHRF1 Antibody
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Anti-UHRF1 Antibody


Anti-UHRF1 Antibody  的详细介绍
Name: Anti-UHRF1 Antibody
See all UHRF1 primary antibodies
Description: Rabbit polyclonal antibody to UHRF1.
Applications: WB, IHC, IF, IP, ChIP
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:20 - 1:50, IP: 1:20 - 1:50, ChIP: 1:20 - 1:50.
Reactivity: Human
Immunogen: Recombinant protein of human UHRF1.
Protein Length: 793
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.
Tissue Specificity: Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
Post-Translational Modification: Phosphorylation at Ser-298 of the linker region decreases the binding to H3K9me3. Phosphorylation at Ser-639 by CDK1 during M phase impairs interaction with USP7, preventing deubiquitination and leading to degradation by the proteasome.
Cellular Location: Nucleus.

Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions.
Database Links:
  • Entrez Gene: 29128?Human
  • Omim: 607990?Human
  • SwissProt: Q96T88?Human
  • Unigene: 108106?Human
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    Synonyms:
  • Ac2-121 Antibody
  • AL022808 Antibody
  • E3 ubiquitin-protein ligase UHRF1 Antibody
  • EC 6.3.2.- Antibody
  • FLJ21925 Antibody
  • hNP95 Antibody
  • hUHRF1 Antibody
  • HuNp95 Antibody
  • ICBP90 Antibody
  • Inverted CCAAT box binding protein of 90 kDa Antibody
  • Inverted CCAAT box binding protein, 90-kD Antibody
  • Inverted CCAAT box-binding protein of 90 kDa Antibody
  • Liver regeneration-related protein LRRG126 Antibody
  • MGC138707 Antibody
  • NP95 Antibody
  • Nuclear phosphoprotein 95 Antibody
  • Nuclear phosphoprotein, 95-KD Antibody
  • Nuclear protein 95 Antibody
  • Nuclear zinc finger protein Np95 Antibody
  • RING finger protein 106 Antibody
  • RNF106 Antibody
  • TDRD22 Antibody
  • Transcription factor ICBP90 Antibody
  • Ubiquitin like containing PHD and RING finger domains protein 1 Antibody
  • Ubiquitin like PHD and RING finger domain containing protein 1 Antibody
  • Ubiquitin-like PHD and RING finger domain-containing protein 1 Antibody
  • Ubiquitin-like protein containing PHD and RING finger domains 1 Antibody
  • Ubiquitin-like with PHD and ring finger domains 1 Antibody
  • Ubiquitin-like, containing PHD and RING finger domains, 1 Antibody
  • Ubiquitin-like-containing PHD and RING finger domains protein 1 Antibody
  • UHRF1 Antibody
  • UHRF1_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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