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Anti-Ubiquitin Antibody

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产品名称: Anti-Ubiquitin Antibody
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Anti-Ubiquitin Antibody


Anti-Ubiquitin Antibody  的详细介绍
Name: Anti-Ubiquitin Antibody
See all Ubiquitin primary antibodies
Description: Rabbit monoclonal antibody to Ubiquitin
Specificity: This antibody detects ubiquitin, polyubiquitin and ubiquitinated proteins.
Applications: WB, ICC/IF, IHC, FC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant antibody.
Host: Rabbit
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: ~ *8 kDa or Uncertain
Purity: Protein A affinity purified
Product Form: Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Function: Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
Sequence Similarities: Belongs to the ubiquitin family.
Post-Translational Modification: Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PARK2), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 7314?Human
  • Entrez Gene: 22187?Mouse
  • Entrez Gene: 192255?Rat
  • SwissProt: P0CG47?Human
  • SwissProt: P0CG48?Human
  • SwissProt: P62979?Human
  • SwissProt: P62987?Human
  • SwissProt: P62988?Human
  • SwissProt: P0CG49?Mouse
  • SwissProt: P62991?Mouse
  • SwissProt: P0CG51?Rat
  • SwissProt: P62989?Rat
  • Unigene: 356190?Human
  • Unigene: 520348?Human
  • Unigene: 282093?Mouse
  • Unigene: 371592?Mouse
  • Unigene: 110618?Rat
  • Unigene: 1253?Rat
  • Unigene: 3761?Rat
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    Synonyms:
  • Epididymis secretory protein Li 50 Antibody
  • FLJ25987 Antibody
  • HEL S 50 Antibody
  • MGC8385 Antibody
  • Polyubiquitin B Antibody
  • RPS 27A Antibody
  • RPS27A Antibody
  • UBA 52 Antibody
  • UBA 80 Antibody
  • UBA52 Antibody
  • UBA80 Antibody
  • UBB Antibody
  • UBB_HUMAN Antibody
  • UBC Antibody
  • UBCEP 1 Antibody
  • UBCEP 2 Antibody
  • UBCEP1 Antibody
  • UBCEP2 Antibody
  • Ubiquitin Antibody
  • Ubiquitin B Antibody
  • UBIQ_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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