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Anti-UBE2L3 Antibody

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产品名称: Anti-UBE2L3 Antibody
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简单介绍

Anti-UBE2L3 Antibody


Anti-UBE2L3 Antibody  的详细介绍
Name: Anti-UBE2L3 Antibody
See all UBE2L3 primary antibodies
Description: Goat polyclonal antibody to UBE2L3.
Applications: ELISA, WB, IF
Reactivity: Human, Mouse, Rat, Porcine
Immunogen: Synthetic peptide corresponding to Human UBE2L3 (C terminal).
Sequence: C-EFTKKYGEKRPVD
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
Sequence Similarities: Belongs to the ubiquitin-conjugating enzyme family.
Post-Translational Modification: Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation. Autoubiquitinated in vitro.
Cellular Location: Nucleus. Cytoplasm.
Database Links:
  • Entrez Gene: 7332 Human
  • Entrez Gene: 100042355 Mouse
  • Entrez Gene: 22195 Mouse
  • Entrez Gene: 363836 Rat
  • Omim: 603721 Human
  • SwissProt: P68036 Human
  • SwissProt: P68037 Mouse
  • Unigene: 108104 Human
  • Unigene: 603229 Human
  • Unigene: 3074 Mouse
  • Unigene: 163186 Rat
    		•
    Synonyms:
  • E2 F1 Antibody
  • L UBC Antibody
  • L-UBC Antibody
  • UB2L3_HUMAN Antibody
  • UBCE7 Antibody
  • UbcH7 Antibody
  • UbcM4 Antibody
  • Ube2L3 Antibody
  • Ubiquitin carrier protein L3 Antibody
  • Ubiquitin conjugating enzyme E2 L3 Antibody
  • Ubiquitin protein ligase L3 Antibody
  • Ubiquitin-conjugating enzyme E2 L3 Antibody
  • Ubiquitin-conjugating enzyme E2-F1 Antibody
  • Ubiquitin-protein ligase L3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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