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Anti-TRPA1 Antibody

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产品名称: Anti-TRPA1 Antibody
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Anti-TRPA1 Antibody


Anti-TRPA1 Antibody  的详细介绍
Name: Anti-TRPA1 Antibody
See all TRPA1 primary antibodies
Description: Rabbit polyclonal antibody to TRPA1.
Applications: WB
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Mouse
Immunogen: A synthetic peptide of human TRPA1.
Protein Length: 1119
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).
Tissue Specificity: Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
Involvement in Disease: Episodic pain syndrome, familial, 1: An autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress. The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating, generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall. Affected individuals do not manifest altered pain sensitivity outside the episodes.
Sequence Similarities: Belongs to the transient receptor (TC 1.A.4) family.
Post-Translational Modification: TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 277328?Mouse
  • SwissProt: Q8BLA8?Mouse
  • Unigene: 186329?Mouse
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    Synonyms:
  • ANKTM 1 Antibody
  • ANKTM1 Antibody
  • Ankyrin-like with transmembrane domains protein 1 Antibody
  • Transformation sensitive protein p120 Antibody
  • Transformation-sensitive protein p120 Antibody
  • Transient receptor potential cation channel subfamily A member 1 Antibody
  • TRPA 1 Antibody
  • TRPA1 Antibody
  • TRPA1_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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