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Anti-STAT4 Antibody

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产品名称: Anti-STAT4 Antibody
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简单介绍

Anti-STAT4 Antibody


Anti-STAT4 Antibody  的详细介绍
Name: Anti-STAT4 Antibody
See all STAT4 primary antibodies
Description: Rabbit polyclonal antibody to STAT4.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human STAT4.
Protein Length: 748
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
Involvement in Disease: Systemic lupus erythematosus 11: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Sequence Similarities: Belongs to the transcription factor STAT family.
Post-Translational Modification: Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
Cellular Location: Cytoplasm. Nucleus.

Translocated into the nucleus in response to phosphorylation.
Database Links:
  • Entrez Gene: 6775?Human
  • Entrez Gene: 20849?Mouse
  • Entrez Gene: 367264?Rat
  • Omim: 600558?Human
  • SwissProt: Q14765?Human
  • SwissProt: P42228?Mouse
  • Unigene: 735572?Human
  • Unigene: 80642?Human
  • Unigene: 1550?Mouse
    		•
    Synonyms:
  • Signal transducer and activator of transcription 4 Antibody
  • SLEB11 Antibody
  • STAT4 Antibody
  • STAT4_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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