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Anti-SNX5 Antibody

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产品名称: Anti-SNX5 Antibody
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Anti-SNX5 Antibody


Anti-SNX5 Antibody  的详细介绍
Name: Anti-SNX5 Antibody
See all SNX5 primary antibodies
Description: Goat polyclonal antibody to SNX5.
Applications: ELISA, WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human SNX5 (C terminal).
Sequence: SLLQSCIDLFKNN
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941).
Sequence Similarities: Belongs to the sorting nexin family.
Cellular Location: Endosome. Early endosome. Early endosome membrane. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasm. Cell projection > Phagocytic cup. Cell projection > Ruffle.

Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation.
Database Links:
  • Entrez Gene: 27131?Human
  • Omim: 605937?Human
  • SwissProt: Q9Y5X3?Human
  • Unigene: 316890?Human
    		•
    Synonyms:
  • 0910001N05Rik Antibody
  • 1810032P22Rik Antibody
  • AU019504 Antibody
  • D2Ertd52e Antibody
  • FLJ10931 Antibody
  • OTTHUMP00000030340 Antibody
  • OTTHUMP00000062927 Antibody
  • OTTMUSP00000003367 Antibody
  • OTTMUSP00000003368 Antibody
  • RP11-504H3.2 Antibody
  • RP23-35E16.2 Antibody
  • snoRNA MBI-43 Antibody
  • SNX 5 Antibody
  • SNX5 Antibody
  • SNX5_HUMAN Antibody
  • Sorting nexin 5 Antibody
  • Sorting nexin-5 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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