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Anti-Rho A+B+C Antibody

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产品名称: Anti-Rho A+B+C Antibody
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Anti-Rho A+B+C Antibody


Anti-Rho A+B+C Antibody  的详细介绍
Name: Anti-Rho A+B+C Antibody
See all Rho A+B+C primary antibodies
Description: Rabbit monoclonal antibody to Rho A+B+C.
Applications: WB, IHC, IF, FC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IF: 1:50 - 1:200, FC: 1:20 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human RHOC.
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
Sequence Similarities: Belongs to the small GTPase superfamily. Rho family.
Post-Translational Modification: (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
Cellular Location: Cell membrane. Cleavage furrow.

Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
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