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Anti-RAD50 Antibody

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产品名称: Anti-RAD50 Antibody
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简单介绍

Anti-RAD50 Antibody


Anti-RAD50 Antibody  的详细介绍
Name: Anti-RAD50 Antibody
See all RAD50 primary antibodies
Description: Rabbit polyclonal antibody to RAD50.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse
Immunogen: A synthetic peptide of human RAD50.
Protein Length: 1312
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).
Tissue Specificity: Expressed at very low level in most tissues, except in testis where it is expressed at higher level. Expressed in fibroblasts.
Involvement in Disease: Nijmegen breakage syndrome-like disorder: A disorder similar to Nijmegen breakage syndrome and characterized by chromosomal instability, radiation sensitivity, microcephaly, growth retardation, short stature and bird-like face. Immunodeficiency is absent.
Sequence Similarities: Belongs to the SMC family. RAD50 subfamily.
Cellular Location: Nucleus. Chromosome > Telomere.

Localizes to discrete nuclear foci after treatment with genotoxic agents.
Database Links:
  • Entrez Gene: 10111?Human
  • Entrez Gene: 19360?Mouse
  • Omim: 604040?Human
  • SwissProt: Q92878?Human
  • SwissProt: P70388?Mouse
  • Unigene: 633509?Human
  • Unigene: 4888?Mouse
    		•
    Synonyms:
  • DNA repair protein RAD50 Antibody
  • hRAD50 Antibody
  • hsRAD50 Antibody
  • Mrell Antibody
  • NBSLD Antibody
  • Rad 50 Antibody
  • Rad50 Antibody
  • RAD50 2 Antibody
  • RAD50 homolog Antibody
  • RAD50 homolog (S cerevisiae) Antibody
  • RAD50 PEN Antibody
  • RAD50, S. cerevisiae, homolog of Antibody
  • RAD502 Antibody
  • Rad50l Antibody
  • RAD50_HUMAN Antibody
  • Truncated RAD50 protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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