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Anti-RAC2 Antibody

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产品名称: Anti-RAC2 Antibody
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简单介绍

Anti-RAC2 Antibody


Anti-RAC2 Antibody  的详细介绍
Name: Anti-RAC2 Antibody
See all RAC2 primary antibodies
Description: Goat polyclonal antibody to RAC2.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human RAC2 (C terminal).
Sequence: PQPTRQQKRACSLL
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Tissue Specificity: Hematopoietic specific.
Involvement in Disease: Neutrophil immunodeficiency syndrome: An immunodeficiency syndrome due to defective neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections and poor wound healing.
Sequence Similarities: Belongs to the small GTPase superfamily. Rho family.
Post-Translational Modification: (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.
Cellular Location: Cytoplasm.

Membrane-associated when activated.
Database Links:
  • Entrez Gene: 5880 Human
  • Omim: 602049 Human
  • SwissProt: P15153 Human
  • Unigene: 517601 Human
    		•
    Synonyms:
  • EN 7 Antibody
  • EN-7 Antibody
  • EN7 Antibody
  • GX Antibody
  • HSPC 022 Antibody
  • HSPC022 Antibody
  • p21 Rac 2 Antibody
  • p21 Rac2 Antibody
  • p21-Rac2 Antibody
  • p21Rac2 Antibody
  • RAC 2 Antibody
  • RAC2 Antibody
  • RAC2_HUMAN Antibody
  • Ras related C3 botulinum toxin substrate 2 Antibody
  • Ras related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2 Antibody
  • Ras related C3 botulinum toxin substrate 3 Antibody
  • Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac2) Antibody
  • Ras-related C3 botulinum toxin substrate 2 Antibody
  • Rho family small GTP binding protein Rac 2 Antibody
  • Rho family small GTP binding protein Rac2 Antibody
  • Small G protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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