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Anti-PNKP Antibody

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Anti-PNKP Antibody


Anti-PNKP Antibody  的详细介绍
Name: Anti-PNKP Antibody
See all PNKP primary antibodies
Description: Rabbit polyclonal antibody to PNKP.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity: Human, Rat
Immunogen: Recombinant protein of human PNKP.
Protein Length: 521
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
Tissue Specificity: Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193).
Involvement in Disease: Microcephaly, seizures, and developmental delay: A disease characterized by infantile-onset seizures, microcephaly, severe intellectual disability and delayed motor milestones with absent speech or only achieving a few words. Most patients also have behavioral problems with hyperactivity. Microcephaly is progressive and without neuronal migration or structural abnormalities, consistent with primary microcephaly.

Ataxia-oculomotor apraxia 4: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy.
Sequence Similarities: In the N-terminal section; belongs to the DNA 3' phosphatase family.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 11284?Human
  • Omim: 605610?Human
  • SwissProt: Q96T60?Human
  • Unigene: 78016?Human
    		•
    Synonyms:
  • 2''(3'')-polynucleotidase Antibody
  • 2'(3')-polynucleotidase Antibody
  • Bifunctional polynucleotide phosphatase/kinase Antibody
  • DEM 1 Antibody
  • DEM1 Antibody
  • DNA 5' kinase/3' phosphatase Antibody
  • DNA 5''-kinase/3''-phosphatase Antibody
  • EIEE10 Antibody
  • Homo sapiens polynucleotide kinase 3' phosphatase (PNKP) Antibody
  • MCSZ Antibody
  • PNK Antibody
  • PNK 1 Antibody
  • PNK1 Antibody
  • Pnkp Antibody
  • PNKP DNA kinase Antibody
  • PNKP_HUMAN Antibody
  • Polynucleotide 3'-phosphatase Antibody
  • Polynucleotide 5' hydroxyl kinase Antibody
  • Polynucleotide 5''-hydroxyl-kinase Antibody
  • Polynucleotide Kinase Antibody
  • Polynucleotide kinase 3 prime phosphatase Antibody
  • Polynucleotide kinase 3' phosphatase Antibody
  • Polynucleotide kinase-3''-phosphatase Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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