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Anti-PARP Antibody

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产品名称: Anti-PARP Antibody
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简单介绍

Anti-PARP Antibody


Anti-PARP Antibody  的详细介绍
Name: Anti-PARP Antibody
See all PARP primary antibodies
Description: Rabbit polyclonal antibody to PARP
Specificity: PARP pAb detects endogenous levels of full length PARP1 (116 kDa), as well as the large fragment (89 kDa) of PARP1 resulting from caspase cleavage.
Applications: WB
Reactivity: Human, Mouse
Immunogen: Recombinant full length Human PARP.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 89, 116 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (PubMed:17177976). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of histones in a HPF1-dependent manner (PubMed:27067600). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Post-Translational Modification: Phosphorylated by PRKDC and TXK.
Cellular Location: Nucleus. Nucleus > Nucleolus.

Localizes at sites of DNA damage.
Database Links:
  • Entrez Gene: 142 Human
  • Entrez Gene: 11545 Mouse
  • Omim: 173870 Human
  • SwissProt: P09874 Human
  • SwissProt: P11103 Mouse
  • Unigene: 177766 Human
  • Unigene: 277779 Mouse
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    Synonyms:
  • ADP ribosyltransferase Antibody
  • ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) Antibody
  • ADP ribosyltransferase diphtheria toxin like 1 Antibody
  • ADP ribosyltransferase NAD(+) Antibody
  • ADPRT Antibody
  • ADPRT 1 Antibody
  • ADPRT1 Antibody
  • ARTD1 Antibody
  • msPARP Antibody
  • NAD(+) ADP ribosyltransferase 1 Antibody
  • NAD(+) ADP-ribosyltransferase 1 Antibody
  • pADPRT 1 Antibody
  • pADPRT1 Antibody
  • PARP Antibody
  • PARP 1 Antibody
  • PARP-1 Antibody
  • PARP1 Antibody
  • PARP1_HUMAN Antibody
  • Poly (ADP ribose) polymerase 1 Antibody
  • poly (ADP ribose) polymerase family, member 1 Antibody
  • Poly [ADP-ribose] polymerase 1 Antibody
  • Poly(ADP ribose) polymerase Antibody
  • poly(ADP ribose) synthetase Antibody
  • poly(ADP ribosyl)transferase Antibody
  • Poly[ADP ribose] synthetase 1 Antibody
  • Poly[ADP-ribose] synthase 1 Antibody
  • PPOL Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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