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Anti-p16 INK4a (A20) Antibody

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产品名称: Anti-p16 INK4a (A20) Antibody
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Anti-p16 INK4a (A20) Antibody


Anti-p16 INK4a (A20) Antibody  的详细介绍
Name: Anti-p16 INK4a (A20) Antibody
See all p16 INK4a primary antibodies
Description: Rabbit polyclonal antibody to p16 INK4a (A20)
Specificity: p16 INK4a (A20) pAb detects endogenous levels of p16-INK4a protein.
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human p16 INK4a.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 16 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Tissue Specificity: Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
Involvement in Disease: Melanoma, cutaneous malignant 2: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.

Familial atypical multiple mole melanoma-pancreatic carcinoma syndrome: An inherited cancer predisposition syndrome characterized by an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer.

Melanoma-astrocytoma syndrome: Characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma.
Sequence Similarities: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Post-Translational Modification: Phosphorylation seems to increase interaction with CDK4.
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 1029 Human
  • Entrez Gene: 12578 Mouse
  • Entrez Gene: 25163 Rat
  • Omim: 600160 Human
  • SwissProt: P42771 Human
  • SwissProt: Q8N726 Human
  • SwissProt: P51480 Mouse
  • SwissProt: Q64364 Mouse
  • SwissProt: Q8QZZ9 Rat
  • SwissProt: Q9R0Z3 Rat
  • Unigene: 512599 Human
  • Unigene: 4733 Mouse
  • Unigene: 48717 Rat
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    Synonyms:
  • ARF Antibody
  • CDK4 inhibitor p16 INK4 Antibody
  • CDK4I Antibody
  • CDKN2 Antibody
  • CDKN2A Antibody
  • CDKN2A/p14ARF Antibody
  • Cell cycle negative regulator beta Antibody
  • CMM2 Antibody
  • Cyclin dependent kinase 4 inhibitor A Antibody
  • Cyclin dependent kinase inhibitor 2A Antibody
  • INK4 Antibody
  • INK4a Antibody
  • Melanoma p16 inhibits CDK4 Antibody
  • MLM Antibody
  • MTS 1 Antibody
  • MTS1 Antibody
  • Multiple tumor suppressor 1 Antibody
  • p14 Antibody
  • p16 Antibody
  • p16 INK4a Antibody
  • p16INK4a Antibody
  • p19 Antibody
  • P19ARF Antibody
  • TP16 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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