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Anti-NFATC1 Antibody

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产品名称: Anti-NFATC1 Antibody
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简单介绍

Anti-NFATC1 Antibody


Anti-NFATC1 Antibody  的详细介绍
Name: Anti-NFATC1 Antibody
See all NFATC1 primary antibodies
Description: Rabbit polyclonal antibody to NFATC1.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human NFATC1.
Protein Length: 943(716)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity).
Tissue Specificity: Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and ***** brain, strongest in corpus callosum.
Post-Translational Modification: Phosphorylated by NFATC-kinase and GSK3B; phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1.
Cellular Location: Cytoplasm. Nucleus.

Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription (PubMed:16511445). Nuclear translocation of NFATC1 is enhanced in the presence of TNFSF11. Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11 (By similarity).
Database Links:
  • Entrez Gene: 4772?Human
  • Entrez Gene: 18018?Mouse
  • Entrez Gene: 100361818?Rat
  • Omim: 600489?Human
  • SwissProt: O95644?Human
  • SwissProt: O88942?Mouse
  • Unigene: 534074?Human
  • Unigene: 701518?Human
  • Unigene: 329560?Mouse
  • Unigene: 229098?Rat
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    Synonyms:
  • cytoplasmic 1 Antibody
  • MGC138448 Antibody
  • NF ATc Antibody
  • NF ATc1 Antibody
  • NF-ATc Antibody
  • NF-ATc1 Antibody
  • NF-ATc1.2 Antibody
  • NFAC1_HUMAN Antibody
  • NFAT 2 Antibody
  • NFAT transcription complex cytosolic component Antibody
  • NFAT2 Antibody
  • NFATc Antibody
  • NFATC 1 Antibody
  • NFATc1 Antibody
  • Nuclear factor of activated T cells cytoplasmic 1 Antibody
  • Nuclear factor of activated T cells cytoplasmic calcineurin dependent 1 Antibody
  • Nuclear factor of activated T cells cytosolic component 1 Antibody
  • Nuclear factor of activated T-cells Antibody
  • nuclear factor of activated T-cells 'c' Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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