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Anti-NELFE Antibody

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产品名称: Anti-NELFE Antibody
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简单介绍

Anti-NELFE Antibody


Anti-NELFE Antibody  的详细介绍
Name: Anti-NELFE Antibody
See all NELFE primary antibodies
Description: Rabbit polyclonal antibody to NELFE.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity: Human, Mouse
Immunogen: Recombinant protein of human NELFE.
Protein Length: 380
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activty of the NELF complex and may initially recruit the NELF complex to RNA. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1.
Tissue Specificity: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
Sequence Similarities: Belongs to the RRM NELF-E family.
Post-Translational Modification: Sumoylated.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 7936?Human
  • Entrez Gene: 27632?Mouse
  • Omim: 154040?Human
  • SwissProt: P18615?Human
  • SwissProt: P19426?Mouse
  • Unigene: 423935?Human
  • Unigene: 279907?Mouse
  • Unigene: 653?Mouse
    		•
    Synonyms:
  • Major histocompatibility complex gene RD Antibody
  • Negative elongation factor E Antibody
  • Negative elongation factor polypeptide E Antibody
  • NELF e Antibody
  • NELF-E Antibody
  • NELFe Antibody
  • NELFE_HUMAN Antibody
  • Nuclear protein Antibody
  • RD Antibody
  • RD protein Antibody
  • RD RNA binding protein Antibody
  • RDP Antibody
  • RNA-binding protein RD Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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