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Anti-Ki-67 Antibody

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产品名称: Anti-Ki-67 Antibody
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简单介绍

Anti-Ki-67 Antibody


Anti-Ki-67 Antibody  的详细介绍
Name: Anti-Ki-67 Antibody
See all Ki67 primary antibodies
Description: Rabbit monoclonal antibody to Ki-67
Specificity: This antibody detects endogenous levels of Ki-67 and does not cross-react with related proteins.
Applications: WB, ICC/IF, IHC, IP, FC
Reactivity: Human
Immunogen: Recombinant antibody.
Host: Rabbit
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: ~ 359 kDa
Purity: Protein A affinity purified
Product Form: Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Function: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
Post-Translational Modification: Phosphorylated. Hyperphosphorylated in mitosis (PubMed:10502411, PubMed:10653604). Hyperphosphorylated form does not bind DNA.
Cellular Location: Chromosome. Nucleus. Nucleus > Nucleolus.

Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106).
Biotechnological Use: Widely used as a marker to assess cell proliferation, as it is detected in the nucleus of proliferating cells only (PubMed:6339421, PubMed:21960707). In cancer research field for example, MKI67 is the most widely used marker for comparing proliferation between tumor samples (PubMed:21960707, PubMed:26680267).
Database Links:
  • Entrez Gene: 4288?Human
  • Omim: 176741?Human
  • SwissProt: P46013?Human
  • Unigene: 689823?Human
  • Unigene: 80976?Human
    		•
    Synonyms:
  • Antigen identified by monoclonal Antibody
  • Antigen KI-67 Antibody
  • Antigen KI67 Antibody
  • Ki67 Antibody
  • KI67_HUMAN Antibody
  • KIA Antibody
  • Marker of proliferation Ki-67 Antibody
  • MIB Antibody
  • MIB 1 Antibody
  • MKI67 Antibody
  • PPP1R105 Antibody
  • Proliferation marker protein Ki-67 Antibody
  • Proliferation related Ki 67 antigen Antibody
  • Protein phosphatase 1 regulatory subunit 105 Antibody
  • RP11-380J17.2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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