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Anti-E2F-1 (D426) Antibody

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产品名称: Anti-E2F-1 (D426) Antibody
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Anti-E2F-1 (D426) Antibody


Anti-E2F-1 (D426) Antibody  的详细介绍
Name: Anti-E2F-1 (D426) Antibody
See all E2F-1 primary antibodies
Description: Rabbit polyclonal antibody to E2F-1 (D426)
Specificity: E2F1 (D426) pAb detects endogenous levels of E2F1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 400-450 of Human E2F-1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 47 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Sequence Similarities: Belongs to the E2F/DP family.
Post-Translational Modification: Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 1869?Human
  • Entrez Gene: 13555?Mouse
  • Entrez Gene: 399489?Rat
  • Omim: 189971?Human
  • SwissProt: Q01094?Human
  • SwissProt: Q61501?Mouse
  • SwissProt: O09139?Rat
  • Unigene: 654393?Human
  • Unigene: 18036?Mouse
  • Unigene: 72471?Rat
    		•
    Synonyms:
  • DmelCG6376 Antibody
  • Dmel_CG6376 Antibody
  • drosE2F1 Antibody
  • E(Sev-CycE)3A Antibody
  • E(var)3-93E Antibody
  • E2-promoter binding facto Antibody
  • E2F 1 Antibody
  • E2F transcription factor 1 Antibody
  • E2F-1 Antibody
  • E2f-PA Antibody
  • E2f-PB Antibody
  • E2f-PC Antibody
  • E2F1 Antibody
  • E2f1 E2F transcription factor 1 Antibody
  • E2F1_HUMAN Antibody
  • Evar(3)164 Antibody
  • KIAA4009 Antibody
  • l(3)07172 Antibody
  • l(3)j3B1 Antibody
  • l(3)j3C2 Antibody
  • l(3)rM729 Antibody
  • mKIAA4009 Antibody
  • OTTHUMP00000030661 Antibody
  • PBR3 Antibody
  • PRB binding protein E2F 1 Antibody
  • PRB-binding protein E2F-1 Antibody
  • RBAP 1 Antibody
  • RBAP-1 Antibody
  • RBAP1 Antibody
  • RBBP-3 Antibody
  • RBBP3 Antibody
  • RBP 3 Antibody
  • RBP3 Antibody
  • Retinoblastoma-associated protein 1 Antibody
  • Retinoblastoma-binding protein 3 Antibody
  • Transcription factor E2F1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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