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Anti-BAX Antibody

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Anti-BAX Antibody


Anti-BAX Antibody  的详细介绍
Name: Anti-BAX Antibody
See all BAX primary antibodies
Description: Rabbit polyclonal antibody to BAX
Specificity: BAX pAb detects endogenous levels of BAX protein.
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide corresponding to residues in Human BAX .
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 18 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Introduction: The Bax protein belongs to a growing family of related Bcl-2 proteins which regulate apoptosis by controlling the permeability of the mitochondrial membrane to the apoptogenic protein cytochrome c. Cytochrome c, in turn, activates the proteolytic proteins known as caspases. The Bcl-2 protein family members play both pro-apoptotic and anti-apoptotic roles, and all possess at least one of four conserved motifs known as "Bcl-2 homology domains" (BH1 to BH4). These domains play key roles as s which allow these proteins to form homodimers or heterodimers, thus regulating the apoptotic activity of these proteins. Bax is a cytosolic protein that plays a pro-apoptotic role by binding to the permeability transition pore complex (PTPC) and by binding Bcl-2, a protein which plays an anti-apoptotic role. The ratio between Bax/Bcl-2 heterodimers and Bax/Bax homodimers appears to be pivotal in determining the lifespan of a cell. Bax exhibits numerous splice variants, including α, β, δ, γ and κ. Bax-β is a 218 amino acid protein. Intron 5 of Bax-beta RNA consists of 630 bp and does not undergo splicing, which accounts for the apparent size increase.
Database Links:
  • Entrez Gene: 581 Human
  • Entrez Gene: 12028 Mouse
  • Entrez Gene: 24887 Rat
  • Omim: 600040 Human
  • SwissProt: Q07812 Human
  • SwissProt: Q07813 Mouse
  • SwissProt: Q63690 Rat
  • Unigene: 624291 Human
  • Unigene: 19904 Mouse
  • Unigene: 10668 Rat
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    Synonyms:
  • Apoptosis regulator BAX Antibody
  • Bax Antibody
  • Bax-protein Antibody
  • BAXA Antibody
  • Baxdelta2G9 Antibody
  • Baxdelta2G9omega Antibody
  • Baxdelta2omega Antibody
  • BAX_HUMAN Antibody
  • Bcl-2-like protein 4 Antibody
  • BCL2 associated X protein Antibody
  • BCL2 associated X protein omega Antibody
  • BCL2 associated X protein transcript variant delta2 Antibody
  • Bcl2-L-4 Antibody
  • BCL2L4 Antibody
  • membrane isoform alpha Antibody
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