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Anti-Bad (F130) Antibody

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产品名称: Anti-Bad (F130) Antibody
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Anti-Bad (F130) Antibody


Anti-Bad (F130) Antibody  的详细介绍
Name: Anti-Bad (F130) Antibody
See all Bad primary antibodies
Description: Rabbit polyclonal antibody to Bad (F130)
Specificity: Bad (F130) pAb detects endogenous levels of Bad protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Bad.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 24 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Tissue Specificity: Expressed in a wide variety of tissues.
Sequence Similarities: Belongs to the Bcl-2 family.
Post-Translational Modification: Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.
Cellular Location: Mitochondrion outer membrane. Cytoplasm.

Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm.
Database Links:
  • Entrez Gene: 572?Human
  • Entrez Gene: 12015?Mouse
  • Entrez Gene: 64639?Rat
  • Omim: 603167?Human
  • SwissProt: Q92934?Human
  • SwissProt: Q61337?Mouse
  • SwissProt: O35147?Rat
  • Unigene: 370254?Human
  • Unigene: 4387?Mouse
  • Unigene: 36696?Rat
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    Synonyms:
  • AI325008 Antibody
  • Bad Antibody
  • BAD_HUMAN Antibody
  • BBC 2 Antibody
  • BBC2 Antibody
  • BBC6 Antibody
  • Bcl 2 Antagonist of Cell Death Antibody
  • Bcl 2 Binding Component 6 Antibody
  • BCL X / BCL 2 Binding Protein Antibody
  • BCL X Binding Protein Antibody
  • Bcl XL/Bcl 2 Associated Death Promoter Antibody
  • Bcl-2-binding component 6 Antibody
  • Bcl-2-like protein 8 Antibody
  • Bcl-XL/Bcl-2-associated death promoter Antibody
  • Bcl2 antagonist of cell death Antibody
  • BCL2 antagonist of cell death protein Antibody
  • BCL2 associated agonist of cell death Antibody
  • Bcl2 Associated Death Promoter Antibody
  • BCL2 binding component 6 Antibody
  • BCL2 binding protein Antibody
  • Bcl2 Like 8 Protein Antibody
  • Bcl2-L-8 Antibody
  • BCL2L8 Antibody
  • Proapoptotic BH3 Only Protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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