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Anti-UNC13D Antibody

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产品名称: Anti-UNC13D Antibody
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简单介绍

Anti-UNC13D Antibody


Anti-UNC13D Antibody  的详细介绍
Name: Anti-UNC13D Antibody
See all UNC13D primary antibodies
Description: Goat polyclonal antibody to UNC13D.
Applications: ELISA, WB, IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to Human UNC13D (internal region).
Sequence: C-ETQKHKKDLHPLFD
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis (By similarity). Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
Tissue Specificity: Mast cells.
Sequence Similarities: Belongs to the unc-13 family.
Cellular Location: Cytoplasm. Membrane. Late endosome. Recycling endosome. Lysosome.

Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.
Database Links:
  • Entrez Gene: 201294?Human
  • Entrez Gene: 70450?Mouse
  • Omim: 608897?Human
  • SwissProt: Q70J99?Human
  • SwissProt: B2RUP2?Mouse
  • Unigene: 41045?Human
  • Unigene: 259460?Mouse
    		•
    Synonyms:
  • FHL 3 Antibody
  • FHL3 Antibody
  • FLJ00067 Antibody
  • HLH 3 Antibody
  • HLH3 Antibody
  • HPLH 3 Antibody
  • HPLH3 Antibody
  • Jinx Antibody
  • Munc 13-4 Antibody
  • Munc13 4 Antibody
  • Munc13-4 Antibody
  • Protein unc 13 homolog D Antibody
  • Protein unc-13 homolog D Antibody
  • UN13D_HUMAN Antibody
  • Unc 13 homolog D Antibody
  • UNC 13D Antibody
  • Unc-13 homolog D (C. elegans) Antibody
  • Unc13 homolog D Antibody
  • Unc13 homolog D (C elegans) Antibody
  • UNC13, C. elegans, homolog of, D Antibody
  • UNC13D Antibody
  • Unc13h4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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