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Anti-UHRF2 Antibody

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产品名称: Anti-UHRF2 Antibody
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Anti-UHRF2 Antibody


Anti-UHRF2 Antibody  的详细介绍
Name: Anti-UHRF2 Antibody
See all UHRF2 primary antibodies
Description: Rabbit polyclonal antibody to UHRF2.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:20 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human UHRF2.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
Post-Translational Modification: May be autoubiquitinated; which may lead to proteasomal degradation.
Cellular Location: Nucleus.

Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity).
Database Links:
  • Entrez Gene: 115426?Human
  • Entrez Gene: 109113?Mouse
  • Entrez Gene: 309331?Rat
  • SwissProt: Q96PU4?Human
  • SwissProt: Q7TMI3?Mouse
  • Unigene: 493401?Human
  • Unigene: 313364?Mouse
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    Synonyms:
  • DKFZp434B0920 Antibody
  • DKFZp686G0837 Antibody
  • E3 ubiquitin-protein ligase UHRF2 Antibody
  • MGC33463 Antibody
  • NIRF Antibody
  • Np95 like RING finger protein Antibody
  • Np95-like ring finger protein Antibody
  • Np95/ICBP90 like RING finger protein Antibody
  • Np95/ICBP90-like RING finger protein Antibody
  • Nuclear protein 97 Antibody
  • Nuclear zinc finger protein Np97 Antibody
  • RING finger protein 107 Antibody
  • RNF 107 Antibody
  • RP11-472F14.2 Antibody
  • Ubiquitin like containing PHD and RING finger domains protein 2 Antibody
  • Ubiquitin-like PHD and RING finger domain-containing protein 2 Antibody
  • Ubiquitin-like-containing PHD and RING finger domains protein 2 Antibody
  • Uhrf2 Antibody
  • UHRF2_HUMAN Antibody
  • URF 2 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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