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Anti-UCHL1 (R202) Antibody

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产品名称: Anti-UCHL1 (R202) Antibody
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Anti-UCHL1 (R202) Antibody


Anti-UCHL1 (R202) Antibody  的详细介绍
Name: Anti-UCHL1 (R202) Antibody
See all UCHL1 primary antibodies
Description: Rabbit polyclonal antibody to UCHL1 (R202)
Specificity: PGP9.5 (R202) pAb detects endogenous levels of PGP9.5 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 171-220 of Human UCHL1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 25 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Tissue Specificity: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
Involvement in Disease: Parkinson disease 5: A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia.

Neurodegeneration with optic atrophy, childhood-onset: A progressive neurodegenerative syndrome characterized by childhood onset blindness, cerebellar ataxia, nystagmus, dorsal column dysfunction, and spasticity with upper motor neuron dysfunction.
Sequence Similarities: Belongs to the peptidase C12 family.
Post-Translational Modification: O-glycosylated.
Cellular Location: Cytoplasm. Endoplasmic reticulum membrane.

About 30% of total UCHL1 is associated with membranes in brain.
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