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Anti-TRIM5 Antibody

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产品名称: Anti-TRIM5 Antibody
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Anti-TRIM5 Antibody


Anti-TRIM5 Antibody  的详细介绍
Name: Anti-TRIM5 Antibody
See all TRIM5 alpha primary antibodies
Description: Goat polyclonal antibody to TRIM5.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human TRIM5 (N terminal).
Sequence: ASGILVNVKEEVTC
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).
Sequence Similarities: Belongs to the TRIM/RBCC family.
Post-Translational Modification: Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.
Cellular Location: Cytoplasm. Cytoplasm > P-body. Nucleus.

Predominantly cytoplasmic, and is only occasionally and partially localized in the nucleus (PubMed:25127057). Closely associates with proteasomal subunits in cytoplasmic bodies (By similarity). Colocalizes with SQSTM1 in cytoplasmic bodies (By similarity).
Database Links:
  • Entrez Gene: 85363 Human
  • Omim: 608487 Human
  • SwissProt: Q9C035 Human
  • Unigene: 370515 Human
    		•
    Synonyms:
  • RING finger protein 88 Antibody
  • RNF88 Antibody
  • TRIM5 Antibody
  • TRIM5 alpha Antibody
  • TRIM5alpha Antibody
  • TRIM5_HUMAN Antibody
  • Tripartite motif containing 5 Antibody
  • tripartite motif protein TRIM5 Antibody
  • Tripartite motif-containing protein 5 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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