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Anti-TOLLIP Antibody

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产品名称: Anti-TOLLIP Antibody
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简单介绍

Anti-TOLLIP Antibody


Anti-TOLLIP Antibody  的详细介绍
Name: Anti-TOLLIP Antibody
See all TOLLIP primary antibodies
Description: Rabbit polyclonal antibody to TOLLIP.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human TOLLIP.
Protein Length: 274
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).
Sequence Similarities: Belongs to the tollip family.
Post-Translational Modification: Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 54472?Human
  • Entrez Gene: 54473?Mouse
  • Entrez Gene: 361677?Rat
  • Omim: 606277?Human
  • SwissProt: Q9H0E2?Human
  • SwissProt: Q9QZ06?Mouse
  • SwissProt: A2RUW1?Rat
  • Unigene: 368527?Human
  • Unigene: 103551?Mouse
  • Unigene: 137040?Rat
    		•
    Synonyms:
  • Adapter protein Antibody
  • FLJ33531 Antibody
  • IL 1RAcPIP Antibody
  • IL1RAcPIP Antibody
  • TOLIP Antibody
  • TOLIP_HUMAN Antibody
  • Toll interacting protein Antibody
  • Toll-interacting protein Antibody
  • Tollip Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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