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Anti-TfR1 (Y20) Antibody

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产品名称: Anti-TfR1 (Y20) Antibody
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Anti-TfR1 (Y20) Antibody


Anti-TfR1 (Y20) Antibody  的详细介绍
Name: Anti-TfR1 (Y20) Antibody
See all TfR1 primary antibodies
Description: Rabbit polyclonal antibody to TfR1 (Y20)
Specificity: TfR1 (Y20) pAb detects endogenous levels of TfR1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to the N-terminus of Human TfR1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 89 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal . Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
Involvement in Disease: Immunodeficiency 46: An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia.
Sequence Similarities: Belongs to the peptidase M28 family. M28B subfamily.
Post-Translational Modification: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Cellular Location: Cell membrane. Melanosome.

Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Database Links:
  • Entrez Gene: 7037?Human
  • Entrez Gene: 22042?Mouse
  • Entrez Gene: 64678?Rat
  • Omim: 190010?Human
  • SwissProt: P02786?Human
  • SwissProt: Q62351?Mouse
  • SwissProt: Q99376?Rat
  • Unigene: 529618?Human
  • Unigene: 28683?Mouse
  • Unigene: 98672?Rat
    		•
    Synonyms:
  • CD 71 Antibody
  • CD71 Antibody
  • CD71 antigen Antibody
  • IMD46 Antibody
  • OTTHUMP00000208523 Antibody
  • OTTHUMP00000208524 Antibody
  • OTTHUMP00000208525 Antibody
  • p90 Antibody
  • sTfR Antibody
  • T9 Antibody
  • TfR Antibody
  • TFR 1 Antibody
  • TfR1 Antibody
  • TFR1_HUMAN Antibody
  • TFRC Antibody
  • TR Antibody
  • Transferrin Receptor Antibody
  • Transferrin receptor (p90 CD71) Antibody
  • Transferrin receptor protein 1, serum form Antibody
  • Trfr Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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