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Anti-TEAD1 Antibody

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产品名称: Anti-TEAD1 Antibody
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简单介绍

Anti-TEAD1 Antibody


Anti-TEAD1 Antibody  的详细介绍
Name: Anti-TEAD1 Antibody
See all TEAD1 primary antibodies
Description: Rabbit polyclonal antibody to TEAD1.
Applications: WB, IHC, IF, IP, ChIP
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:50 - 1:200, ChIP: 1:20 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human TEAD1.
Protein Length: 426 (412)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Tissue Specificity: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Involvement in Disease: Sveinsson chorioretinal atrophy: Characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 7003?Human
  • Entrez Gene: 21676?Mouse
  • Entrez Gene: 361630?Rat
  • Omim: 189967?Human
  • SwissProt: P28347?Human
  • SwissProt: P30051?Mouse
  • Unigene: 655331?Human
  • Unigene: 24685?Mouse
  • Unigene: 398985?Mouse
    		•
    Synonyms:
  • AA Antibody
  • Atrophia areata peripapillary chorioretinal degeneration Antibody
  • NTEF 1 Antibody
  • NTEF-1 Antibody
  • NTEF1 Antibody
  • Protein GT IIC Antibody
  • Protein GT-IIC Antibody
  • REF 1 Antibody
  • REF1 Antibody
  • SV40 transcriptional enhancer factor Antibody
  • TCF 13 Antibody
  • TCF-13 Antibody
  • TCF13 Antibody
  • TEA domain family member Antibody
  • TEA domain family member 1 Antibody
  • TEA domain family member 1 (SV40 transcriptional enhancer factor) Antibody
  • TEAD 1 Antibody
  • TEAD 1 protein Antibody
  • TEAD-1 Antibody
  • TEAD1 Antibody
  • TEAD1 protein Antibody
  • TEAD1_HUMAN Antibody
  • TEF 1 Antibody
  • TEF1 Antibody
  • Transcription factor 13 Antibody
  • Transcription factor 13 (SV40 transcriptional enhancer factor) Antibody
  • Transcriptional enhancer factor 1 Antibody
  • Transcriptional enhancer factor TEF-1 Antibody
  • Transcriptional enhancer factor TEF1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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