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Anti-SNRPE Antibody

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产品名称: Anti-SNRPE Antibody
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Anti-SNRPE Antibody


Anti-SNRPE Antibody  的详细介绍
Name: Anti-SNRPE Antibody
See all SNRPE primary antibodies
Description: Rabbit polyclonal antibody to SNRPE.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SNRPE.
Protein Length: 92
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.
Tissue Specificity: Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis.
Involvement in Disease: Hypotrichosis 11: A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT11 is characterized by scanty or absent eyebrows and a highly variable degree of alopecia since birth, ranging from slight thinning of scalp and axillary hair to complete loss of scalp and body hair. Pubic hair remains mainly unaffected.
Sequence Similarities: Belongs to the snRNP Sm proteins family.
Cellular Location: Cytoplasm > Cytosol. Nucleus.

SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Database Links:
  • Entrez Gene: 6635?Human
  • Entrez Gene: 20643?Mouse
  • Entrez Gene: 685587?Rat
  • Omim: 128260?Human
  • SwissProt: P62304?Human
  • SwissProt: P62305?Mouse
  • Unigene: 334612?Human
  • Unigene: 654418?Human
  • Unigene: 249110?Mouse
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    Synonyms:
  • AL022645 Antibody
  • B raf Antibody
  • B-raf Antibody
  • Braf Antibody
  • C76690 Antibody
  • HYPT11 Antibody
  • RUXE_HUMAN Antibody
  • Sm protein E Antibody
  • Sm-E Antibody
  • Small nuclear ribonucleoprotein E Antibody
  • SmE Antibody
  • snRNP-E Antibody
  • snRNPE Antibody
  • SNRPE Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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