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Anti-RANKL (A72) Antibody

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产品名称: Anti-RANKL (A72) Antibody
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Anti-RANKL (A72) Antibody


Anti-RANKL (A72) Antibody  的详细介绍
Name: Anti-RANKL (A72) Antibody
See all RANKL primary antibodies
Description: Rabbit polyclonal antibody to RANKL (A72)
Specificity: RANKL (A72) pAb detects endogenous levels of RANKL protein.
Applications: WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 51-100 of Human RANKL.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 40 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).
Tissue Specificity: Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
Involvement in Disease: Osteopetrosis, autosomal recessive 2: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or *****hood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.
Sequence Similarities: Belongs to the tumor necrosis factor family.
Post-Translational Modification: The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 8600 Human
  • Entrez Gene: 21943 Mouse
  • Entrez Gene: 117516 Rat
  • Omim: 602642 Human
  • SwissProt: O14788 Human
  • SwissProt: O35235 Mouse
  • SwissProt: Q9ESE2 Rat
  • Unigene: 333791 Human
  • Unigene: 249221 Mouse
  • Unigene: 217570 Rat
  • Unigene: 64517 Rat
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    Synonyms:
  • CD254 Antibody
  • hRANKL2 Antibody
  • ODF Antibody
  • OPGL Antibody
  • OPTB2 Antibody
  • Osteoclast differentiation factor Antibody
  • Osteoprotegerin ligand Antibody
  • RANKL Antibody
  • Receptor activator of nuclear factor kappa B ligand Antibody
  • Receptor activator of nuclear factor kappa-B ligand Antibody
  • sOdf Antibody
  • TNF related activation induced cytokine Antibody
  • TNF-related activation-induced cytokine Antibody
  • TNF11_HUMAN Antibody
  • TNFSF 11 Antibody
  • Tnfsf11 Antibody
  • TRANCE Antibody
  • Tumor necrosis factor (ligand) superfamily member 11 Antibody
  • Tumor necrosis factor ligand superfamily member 11 Antibody
  • Tumor necrosis factor ligand superfamily member 11, soluble form Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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