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Anti-Oct-3/4 (K222) Antibody

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产品名称: Anti-Oct-3/4 (K222) Antibody
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Anti-Oct-3/4 (K222) Antibody


Anti-Oct-3/4 (K222) Antibody  的详细介绍
Name: Anti-Oct-3/4 (K222) Antibody
See all Oct-03 primary antibodies
Description: Rabbit polyclonal antibody to Oct-3/4 (K222)
Specificity: OCT3/4 (K222) pAb detects endogenous levels of POU domain, class 5, transcription factor 1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 200-250 of Human Oct-3/4.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 39 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Tissue Specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in ***** tissues.
Sequence Similarities: Belongs to the POU transcription factor family. Class-5 subfamily.
Post-Translational Modification: Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity).
Cellular Location: Cytoplasm. Nucleus.

Expressed in a diffuse and slightly punctuate pattern.
Biotechnological Use: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
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