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Anti-Nrf2 (phospho-S40) Antibody

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产品名称: Anti-Nrf2 (phospho-S40) Antibody
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Anti-Nrf2 (phospho-S40) Antibody


Anti-Nrf2 (phospho-S40) Antibody  的详细介绍
Name: Anti-Nrf2 (phospho-S40) Antibody
See all Nrf2 primary antibodies
Description: Rabbit monoclonal antibody to Nrf2 (phospho-S40)
Specificity: This antibody detects endogenous levels of Nrf2 only when phosphorylated at Ser40.
Applications: WB, ICC/IF, IHC, FC
Reactivity: Human
Immunogen: Recombinant antibody.
Host: Rabbit
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: ~ 68, 90 kDa
Purity: Protein A affinity purified
Product Form: Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Tissue Specificity: Widely expressed. Highest expression in ***** muscle, kidney, lung, liver and in fetal muscle.
Sequence Similarities: Belongs to the bZIP family. CNC subfamily.
Post-Translational Modification: Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
Cellular Location: Cytoplasm > Cytosol. Nucleus.

Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Database Links:
  • Entrez Gene: 4780?Human
  • Omim: 600492?Human
  • SwissProt: Q16236?Human
  • Unigene: 744006?Human
    		•
    Synonyms:
  • erythroid derived 2 Antibody
  • HEBP1 Antibody
  • like 2 Antibody
  • NF E2 related factor 2 Antibody
  • NF-E2-related factor 2 Antibody
  • NF2L2_HUMAN Antibody
  • NFE2 related factor 2 Antibody
  • NFE2-related factor 2 Antibody
  • Nfe2l2 Antibody
  • Nrf 2 Antibody
  • Nrf2 Antibody
  • Nuclear factor Antibody
  • Nuclear factor (erythroid derived 2) like 2 Antibody
  • nuclear factor erythroid 2 like 2 Antibody
  • Nuclear factor erythroid 2 related factor 2 Antibody
  • Nuclear factor erythroid 2-related factor 2 Antibody
  • Nuclear factor erythroid derived 2 like 2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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