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Anti-NOS3 (S1170) Antibody

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产品名称: Anti-NOS3 (S1170) Antibody
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Anti-NOS3 (S1170) Antibody


Anti-NOS3 (S1170) Antibody  的详细介绍
Name: Anti-NOS3 (S1170) Antibody
See all NOS3 primary antibodies
Description: Rabbit polyclonal antibody to NOS3 (S1170)
Specificity: NOS3 (S1170) pAb detects endogenous levels of NOS3 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 1140-1190 of Human NOS3.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 140 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Tissue Specificity: Platelets, placenta, liver and kidney.
Sequence Similarities: Belongs to the NOS family.
Post-Translational Modification: Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity (By similarity). Phosphorylation of Ser-114 by CDK5 reduces activity.
Cellular Location: Cell membrane. Membrane > Caveola. Cytoplasm > Cytoskeleton. Golgi apparatus.

Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
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