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Anti-NOL3 Antibody

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产品名称: Anti-NOL3 Antibody
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简单介绍

Anti-NOL3 Antibody


Anti-NOL3 Antibody  的详细介绍
Name: Anti-NOL3 Antibody
See all NOL3 primary antibodies
Description: Rabbit polyclonal antibody to NOL3.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human NOL3.
Protein Length: 219 (208)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Isoform 1: May be involved in RNA splicing.
Tissue Specificity: Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver, kidney and pancreas.
Involvement in Disease: Myoclonus, familial cortical: An autosomal dominant neurologic condition characterized by ***** onset of cortical myoclonus manifest as involuntary jerks or movements affecting the face and limbs. Affected individuals can also experience falls without seizure activity or loss of consciousness.
Post-Translational Modification: Phosphorylation at Thr-149 is required for its antiapoptotic effect by blocking death-inducing signaling complex death-inducing signaling complex (DISC) activity through the control of interaction with CASP8. Phosphorylation at Thr-149 results in translocation to mithochondria and this translocation enables the binding to CASP8. Dephosphorylated at Thr-149 by calcineurin; doesn't inhibit the association between FADD and CASP8 and the consequent apoptosis.
Cellular Location: Nucleus > Nucleolus.

The SR-rich C-terminus mediates nuclear localization.
Database Links:
  • Entrez Gene: 8996?Human
  • Entrez Gene: 78688?Mouse
  • Entrez Gene: 85383?Rat
  • Omim: 605235?Human
  • SwissProt: O60936?Human
  • SwissProt: Q9D1X0?Mouse
  • SwissProt: Q62881?Rat
  • Unigene: 513667?Human
  • Unigene: 204876?Mouse
  • Unigene: 475715?Mouse
  • Unigene: 86956?Rat
    		•
    Synonyms:
  • Apoptosis repressor with CARD Antibody
  • ARC Antibody
  • Muscle enriched cytoplasmic protein Antibody
  • Muscle-enriched cytoplasmic protein Antibody
  • MYC Antibody
  • MYP Antibody
  • Nol3 Antibody
  • NOL3_HUMAN Antibody
  • NOP Antibody
  • Nop30 Antibody
  • Nucleolar protein 3 Antibody
  • Nucleolar protein 3 (apoptosis repressor with CARD domain) Antibody
  • Nucleolar protein of 30 kDa Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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