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Anti-NF-kB p65 Antibody

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产品名称: Anti-NF-kB p65 Antibody
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Anti-NF-kB p65 Antibody


Anti-NF-kB p65 Antibody  的详细介绍
Name: Anti-NF-kB p65 Antibody
See all NF-kB p65 primary antibodies
Description: Rabbit monoclonal antibody to NF-kB p65
Specificity: This antibody detects endogenous levels of NF-kB p65 and does not cross-react with related proteins.
Applications: WB, ICC/IF, IHC, FC
Reactivity: Human, Mouse, Zebrafish
Immunogen: Recombinant antibody.
Host: Rabbit
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: ~ 65 kDa
Purity: Protein A affinity purified
Product Form: Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA- which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).
Post-Translational Modification: Ubiquitinated, leading to its proteasomal degradation. Degradation is required for termination of NF-kappa-B response.
Cellular Location: Nucleus. Cytoplasm.

Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation.
Database Links:
  • Entrez Gene: 5970?Human
  • Entrez Gene: 19697?Mouse
  • Omim: 164014?Human
  • SwissProt: Q04206?Human
  • SwissProt: Q04207?Mouse
  • Unigene: 502875?Human
  • Unigene: 249966?Mouse
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    Synonyms:
  • Avian reticuloendotheliosis viral (v rel) oncogene homolog A Antibody
  • MGC131774 Antibody
  • NF kappa B p65delta3 Antibody
  • NF-kB p65 Antibody
  • NFKB3 Antibody
  • Nuclear Factor NF Kappa B p65 Subunit Antibody
  • Nuclear factor NF-kappa-B p65 subunit Antibody
  • Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 Antibody
  • Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 Antibody
  • OTTHUMP00000233473 Antibody
  • OTTHUMP00000233474 Antibody
  • OTTHUMP00000233475 Antibody
  • OTTHUMP00000233476 Antibody
  • OTTHUMP00000233900 Antibody
  • p65 Antibody
  • p65 NF kappaB Antibody
  • p65 NFkB Antibody
  • relA Antibody
  • TF65_HUMAN Antibody
  • Transcription factor p65 Antibody
  • V rel avian reticuloendotheliosis viral oncogene homolog A Antibody
  • v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)) Antibody
  • v rel reticuloendotheliosis viral oncogene homolog A (avian) Antibody
  • V rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B cells 3, p65 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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