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Anti-Mcl-1 (S121) Antibody

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产品名称: Anti-Mcl-1 (S121) Antibody
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Anti-Mcl-1 (S121) Antibody


Anti-Mcl-1 (S121) Antibody  的详细介绍
Name: Anti-Mcl-1 (S121) Antibody
See all Mcl1 primary antibodies
Description: Rabbit polyclonal antibody to Mcl-1 (S121)
Specificity: MCL1 (S121) pAb detects endogenous levels of MCL1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Mcl-1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 37 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Sequence Similarities: Belongs to the Bcl-2 family.
Post-Translational Modification: Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
Cellular Location: Membrane. Cytoplasm. Mitochondrion. Nucleus > Nucleoplasm.

Cytoplasmic, associated with mitochondria.
Database Links:
  • Entrez Gene: 4170?Human
  • Entrez Gene: 17210?Mouse
  • Entrez Gene: 60430?Rat
  • Omim: 159552?Human
  • SwissProt: Q07820?Human
  • SwissProt: P97287?Mouse
  • SwissProt: Q9Z1P3?Rat
  • Unigene: 632486?Human
  • Unigene: 1639?Mouse
  • Unigene: 161889?Rat
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    Synonyms:
  • Bcl 2 related protein EAT/mcl1 Antibody
  • Bcl-2-like protein 3 Antibody
  • Bcl-2-related protein EAT/mcl1 Antibody
  • BCL2 related Antibody
  • Bcl2-L-3 Antibody
  • BCL2L3 Antibody
  • EAT Antibody
  • Induced myeloid leukemia cell differentiation protein Mcl 1 Antibody
  • Induced myeloid leukemia cell differentiation protein Mcl-1 Antibody
  • MCL 1 Antibody
  • MCL1 Antibody
  • MCL1-ES Antibody
  • mcl1/EAT Antibody
  • MCL1L Antibody
  • MCL1S Antibody
  • MCL1_HUMAN Antibody
  • MGC104264 Antibody
  • MGC1839 Antibody
  • Myeloid Cell Leukemia 1 Antibody
  • Myeloid cell leukemia ES Antibody
  • Myeloid cell leukemia sequence 1 Antibody
  • Myeloid cell leukemia sequence 1 BCL2 related Antibody
  • Myeloid cell leukemia sequence 1 isoform 1 Antibody
  • OTTHUMP00000032794 Antibody
  • OTTHUMP00000032795 Antibody
  • TM Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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