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Anti-MAP1LC3A Antibody

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产品名称: Anti-MAP1LC3A Antibody
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简单介绍

Anti-MAP1LC3A Antibody


Anti-MAP1LC3A Antibody  的详细介绍
Name: Anti-MAP1LC3A Antibody
See all MAP1LC3A primary antibodies
Description: Rabbit monoclonal antibody to MAP1LC3A
Specificity: This antibody detects endogenous levels of MAP1LC3A and does not cross-react with related proteins.
Applications: WB, ICC/IF, IHC, FC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant antibody.
Host: Rabbit
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: ~ 14 kDa
Purity: Protein A affinity purified
Product Form: Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).
Tissue Specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
Sequence Similarities: Belongs to the ATG8 family.
Post-Translational Modification: The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).
Cellular Location: Cytoplasm > Cytoskeleton. Endomembrane system. Cytoplasmic vesicle > Autophagosome membrane. Cytoplasmic vesicle > Autophagosome.

LC3-II binds to the autophagic membranes.
Database Links:
  • Entrez Gene: 84557?Human
  • Entrez Gene: 66734?Mouse
  • Entrez Gene: 362245?Rat
  • Omim: 601242?Human
  • SwissProt: Q9H492?Human
  • SwissProt: Q91VR7?Mouse
  • SwissProt: Q6XVN8?Rat
  • Unigene: 632273?Human
  • Unigene: 196239?Mouse
  • Unigene: 3135?Rat
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    Synonyms:
  • ATG8E Antibody
  • Autophagy-related protein LC3 A Antibody
  • Autophagy-related ubiquitin-like modifier LC3 A Antibody
  • LC3 Antibody
  • LC3A Antibody
  • MAP1 light chain 3 like protein 1 Antibody
  • MAP1 light chain 3-like protein 1 Antibody
  • MAP1A/1B light chain 3 A Antibody
  • MAP1A/MAP1B LC3 A Antibody
  • MAP1A/MAP1B light chain 3 A Antibody
  • MAP1ALC3 Antibody
  • MAP1BLC3 Antibody
  • MAP1LC3A Antibody
  • Microtubule associated proteins 1A/1B light chain 3 Antibody
  • Microtubule-associated protein 1 light chain 3 alpha Antibody
  • Microtubule-associated proteins 1A and 1B, light chain 3 Antibody
  • Microtubule-associated proteins 1A/1B light chain 3A Antibody
  • MLP3A_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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