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Anti-LRP1 Antibody

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产品名称: Anti-LRP1 Antibody
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简单介绍

Anti-LRP1 Antibody


Anti-LRP1 Antibody  的详细介绍
Name: Anti-LRP1 Antibody
See all LRP1 primary antibodies
Description: Rabbit monoclonal antibody to LRP1.
Applications: WB, IHC, IF, IP, FC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IF: 1:50 - 1:100, IP: 1:20 - 1:50, FC: 1:10 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human LRP1.
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
Tissue Specificity: Most abundant in liver, brain and lung.
Sequence Similarities: Belongs to the LDLR family.
Post-Translational Modification: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.
Cellular Location: Cell membrane. Membrane > Coated pit.
Database Links:
  • Entrez Gene: 4035?Human
  • Entrez Gene: 16971?Mouse
  • Entrez Gene: 299858?Rat
  • Omim: 107770?Human
  • SwissProt: Q07954?Human
  • SwissProt: Q91ZX7?Mouse
  • Unigene: 162757?Human
  • Unigene: 271854?Mouse
  • Unigene: 22436?Rat
    		•
    Synonyms:
  • A2MR Antibody
  • Alpha 2 macroglobulin receptor Antibody
  • alpha 2MR Antibody
  • Alpha-2-macroglobulin receptor Antibody
  • APOER Antibody
  • Apolipoprotein E receptor Antibody
  • APR Antibody
  • CD 91 Antibody
  • CD91 Antibody
  • CD91 antigen Antibody
  • IGFBP3R Antibody
  • LDL receptor related protein 1 Antibody
  • Low density lipoprotein receptor related protein 1 Antibody
  • Low density lipoprotein related protein 1 Antibody
  • Low-density lipoprotein receptor-related protein 1 intracellular domain Antibody
  • LRP Antibody
  • LRP 1 Antibody
  • LRP 515 Antibody
  • LRP 85 Antibody
  • LRP ICD Antibody
  • LRP-1 Antibody
  • LRP-515 Antibody
  • LRP-85 Antibody
  • LRP1 Antibody
  • LRP1 protein Antibody
  • LRP1A Antibody
  • LRP1_HUMAN Antibody
  • LRP515 Antibody
  • LRP85 Antibody
  • LRPICD Antibody
  • MGC88725 Antibody
  • Prolow density lipoprotein receptor related protein 1 Antibody
  • TbetaR V/LRP 1/IGFBP 3 receptor Antibody
  • TbetaRV/LRP1/IGFBP3 receptor Antibody
  • TGFBR 5 Antibody
  • TGFBR5 Antibody
  • Type V tgf beta receptor Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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