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Anti-HSP27 (phospho-S78) Antibody

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产品名称: Anti-HSP27 (phospho-S78) Antibody
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Anti-HSP27 (phospho-S78) Antibody


Anti-HSP27 (phospho-S78) Antibody  的详细介绍
Name: Anti-HSP27 (phospho-S78) Antibody
See all HSP27 primary antibodies
Description: Rabbit polyclonal antibody to HSP27 (phospho-S78)
Specificity: p-HSP27 (Ser78) pAb detects endogenous levels of HSP27 protein only when phosphorylated at Ser78
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human HSP27 around the phosphorylation site of Serine 78.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 27 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Function: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742).
Tissue Specificity: Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle.
Involvement in Disease: Charcot-Marie-Tooth disease 2F: A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Onset of Charcot-Marie-Tooth disease type 2F is between 15 and 25 years with muscle weakness and atrophy usually beginning in feet and legs (peroneal distribution). Upper limb involvement occurs later.

Neuronopathy, distal hereditary motor, 2B: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
Sequence Similarities: Belongs to the small heat shock protein (HSP20) family.
Post-Translational Modification: Phosphorylated upon exposure to protein kinase C activators and heat shock (PubMed:8325890). Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:8093612, PubMed:19166925).
Cellular Location: Cytoplasm. Nucleus. Cytoplasm > Cytoskeleton > Spindle.

Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Database Links:
  • Entrez Gene: 3315?Human
  • Entrez Gene: 15507?Mouse
  • Entrez Gene: 24471?Rat
  • Omim: 602195?Human
  • SwissProt: P04792?Human
  • SwissProt: P14602?Mouse
  • SwissProt: P42930?Rat
  • Unigene: 520973?Human
  • Unigene: 13849?Mouse
  • Unigene: 3841?Rat
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    Synonyms:
  • Heat shock 27kDa protein Antibody
  • 28 kDa heat shock protein Antibody
  • CMT2F Antibody
  • DKFZp586P1322 Antibody
  • epididymis secretory protein Li 102 Antibody
  • Estrogen regulated 24 kDa protein Antibody
  • Estrogen-regulated 24 kDa protein Antibody
  • Heat shock 25kDa protein 1 Antibody
  • Heat shock 27 kDa protein Antibody
  • Heat shock 27kD protein 1 Antibody
  • Heat shock 27kDa protein 1 Antibody
  • Heat shock 28kDa protein 1 Antibody
  • Heat Shock Protein 27 Antibody
  • Heat shock protein beta 1 Antibody
  • Heat shock protein beta-1 Antibody
  • heat shock protein family B (small) member 1 Antibody
  • HEL-S-102 Antibody
  • HMN2B Antibody
  • HS.76067 Antibody
  • Hsp 25 Antibody
  • HSP 27 Antibody
  • Hsp 28 Antibody
  • Hsp B1 Antibody
  • Hsp25 Antibody
  • Hsp27 Antibody
  • Hsp28 Antibody
  • HspB1 Antibody
  • HSPB1_HUMAN Antibody
  • SRP27 Antibody
  • Stress responsive protein 27 Antibody
  • Stress-responsive protein 27 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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